LyosenseTM. Lyophilisation process control. Poster presentation at: UK-PharmSci; 2010 Sept 1-3; Nottingham, UK
Cite as : Smith G et al (2010) LyosenseTM. Lyophilisation process control. Poster presentation at: UK-PharmSci; 2010 Sept 1-3; Nottingham, UK
The aim of this work is to develop an individual
vial monitoring system (Lyosense™) for characterizing lyophile product
characteristics and process end points to establish and control lyophilization
regimes.
LyosenseTM is
a process analytical technology based on dielectric analysis of the
lyophilization process. The system measures the pseudo-relaxation process associated
with the interfacial polarization of the glass wall, through the resistance of
the sample. This process undergoes characteristic changes in amplitude and peak
frequency, such that the progress of freeze-drying and condition of the sample
can be controlled.
Abstracts from the UK-Pharmsci Conference, 1–3 September 2010
