Smith G (2022) Oxford Global Formulation & Delivery May 5_6 with notes.pptx (112.39 MB)
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Smith, G. (2022) Freeze-drying for the stabilization of drug products: Recent developments in process analytical technologies. Podium presentation at Oxford Global Formulation and Delivery UK. London 5-6 May

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posted on 2022-12-15, 09:59 authored by Geoff SmithGeoff Smith

  

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Smith, G. (2022) Freeze-drying for the stabilization of drug products: Recent developments in process analytical technologies. Podium presentation at Oxford Global Formulation and Delivery UK. London 5-6 May 2022 

Topics covered by this talk:

  • Why freeze-dry?
  • Process analytical technologies for freeze-drying (single vial and batch techniques)
  • Introduction to through-via impedance spectroscopy (TVIS) 
  • Case study : Primary drying end point
  • Separation between sublimation (primary drying) and diffusive desorption (secondary drying)
  • The impact of phase states (crystalline vs amorphous) on the end point profile

  

Conclusion: Existing, vapour and temperature sensing PATs cannot differentiate between source of water vapour (ice or adsorbed water).TVIS provides identification of true sublimation (primary drying) end point

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