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Smith G (2023) Marcus Evans 14th Biologics Formulation, Development And Drug Delivery Sept 14-15th.pdf (3.38 MB)

Smith G (2023) Electrical impedance PAT for biotherapeutic freeze-drying. Marcus Evans 14th Biologics Formulation, Development And Drug Delivery Sept 14-15th

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posted on 2023-09-21, 19:03 authored by Geoff SmithGeoff Smith

Podium presentation at Marcus Evans 14th Biologics Formulation, Development And Drug Delivery Series Sept 14-15th 2023, London

Cite as: Smith, G. (2023) Electrical impedance PAT for biotherapeutic freeze-drying. Podium presentation at Marcus Evans 14th Biologics Formulation, Development And Drug Delivery Series, London UK. 14-15 Sept 2023

The talk introduces the technology known as through-vial impedance spectroscopy (TVIS) and its use in the investigation of the freeze-drying of pharmaceutical drug products. The facets of the lyophilization process described in the talk are:

  • The ice nucleation temperature and ice solidification time
  • The prediction of the ice mass temperature during the primary drying stage
  • The characterization of the annealing end point
  • The determination of the dry layer resistance

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